before anything: could you share this input file publicly by any chance? (if not) could you try with current upstream master of nibabel which progressed forward quite a bit without a release: 2.1.0-370-gf5dec180
and also -- what version of python-dicom you have? I guess 0.9.9... (that is where exception comes from). upstream also progressed quite forward without a release v0.9.9-448-g5b4d0f3 https://github.com/darcymason/pydicom/ but probably it is just that indeed some rare JPEG2000 or smth like that was used to compress the data, which pydicom doesn't handle. I wish pydicom provided a bit more informative exception though ;) -- Yaroslav O. Halchenko Center for Open Neuroscience http://centerforopenneuroscience.org Dartmouth College, 419 Moore Hall, Hinman Box 6207, Hanover, NH 03755 Phone: +1 (603) 646-9834 Fax: +1 (603) 646-1419 WWW: http://www.linkedin.com/in/yarik