Dear Maintainer, It seems that the issue is not yet resolved. Therefore, a fresh pyspread currently is broken on non-gtk2 systems. This is also reflected in the current CI test log.
Pyspread requires the files pango.so and pangocairo.so to be in the PYTHONPATH. On my system (sid), the folder is /usr/lib/python2.7/dist-packages/gtk-2.0/ apt-file tells me that these files are provided be the package python-gtk2 Therefore, I suggest adding python-gtk2 as a dependency to pyspread.