sgfxi is a script that will install the latest proprietary drivers for you, I guess it doesn't really matter in this situation. Anyway, that's odd that you can set keys with the default root permissions while I can't. However, I seem to have found a temporary fix that seems to be working great for me so far.
sudo setfacl -b /dev/input/event4 This prevents mumble from using my keyboard media keys and causes mumble to fallback to xinput. GlobalShortcutX: Unable to open any keyboard input devices under /dev/input, falling back to XInput GlobalShortcutX: Using XI2 2.0 Now it lets me use shortcuts again.