> Avoid multimethods and other global registries like re-frame. These 
thwart DCE because there’s no way to know at compile time that a specific 
method/handler is never used.

Isn't this advice only applicable to libraries which have a lot of 
multimethods in the implementation? If the project codebase itself (not the 
libraries) contains multimethods then I suppose they are all needed in 
production potentially and thus should never be eliminated.

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