Thanks for the link Chris. I've actually read over this wiki link before, but 
didn't think about it too hard. I was hoping I wouldn't have to make drastic 
changes to the infrastructure to handle my particular use, but it seems that 
might be the case. If I'm going to essentially write my own messaging bus that 
handles dynamic subscriptions and many to many handlers, I should probably just 
not bother with re-frame. The other quirk that kind of bothers me is how each 
handler defines its own middleware. I tend to think of middleware as an 
application-wide orthogonal offering for logging, debugging, reporting, etc. I 
don't like the idea of having to manually insert middleware for each and every 
handler, even if I generate a middleware factory. 

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