Hi Joshua and all - regarding https://bugs.gnu.org/35322, I have (finally) pushed your patches. I tweaked the doc update a little bit and created a new test to try out the --with-python_prefix and --with-python_exec_prefix options. (I left the underscores in the name since I saw there were other such cases already. Confusing either way, so fine.)
Thanks much for doing all the work. --karl